https://www.selleckchem.com/pr....oducts/pkm2-inhibito
A series of fluorescent dibenzodiazepinone-type muscarinic acetylcholine M2 receptor (M2R) ligands was synthesized using various fluorescent dyes (5-TAMRA, λex/λem ≈ 547/576 nm; BODIPY 630/650, λex/λem ≈ 625/640 nm; pyridinium dye Py-1, λex/λem ≈ 611/665 nm and pyridinium dye Py-5, λex/λem ≈ 465/732 nm). All fluorescent probes exhibited high M2R affinity (pKi (radioligand competition binding) 8.75-9.62, pKd (flow cytometry) 8.36-9.19), a very low preference for the M2R over the M1 and M4 receptors and moderate to pron
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