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Multidisciplinary team management is mandatory in order to estimate the optimal treatment regimen. GERMS.Introduction Co-infection has become a major contributor to increased burden of morbidity and mortality in HIV infection. The aim of this study was to assess the prevalence of asymptomatic malaria in the HIV-infected subjects on antimalarial prophylaxis and provide information to improve management of HIV subjects. Methods This was a cross-sectional study with a purposive sampling. Microscopy method was used for the confirmation of mala