https://molibresibinhibitor.co....m/higher-education-a
Using intravital imaging, we demonstrate that invading cells show dorsoventral (top-to-bottom) polarity in vivo. To investigate the impact of dorsoventral polarity on mobile locomotion through different confining geometries, we fabricated microchannels of fixed cross-sectional area, albeit with distinct aspect ratios. Straight confinement, exerted along the dorsoventral polarity axis, causes myosin II-dependent nuclear stiffening, which causes RhoA hyperactivation at the cellular poles and
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