https://www.selleckchem.com/pr....oducts/bicuculline.h
Thus, PRPF19 plays an important role in the induction of p53-dependent cellular senescence.More than half a century ago, reversible protein phosphorylation was linked to mitochondrial metabolism through the regulation of pyruvate dehydrogenase. Since this discovery, the number of identified mitochondrial protein phosphorylation sites has increased by orders of magnitude, driven largely by technological advances in mass spectrometry-based phosphoproteomics. However, the majority of these modifications remain uncharacterized, renderin