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This study confirmed that, like humans, there may be ECG changes secondary to normal physiological cardiac aging. Further studies are warranted to confirm and elaborate on these findings as canines may be a useful model for cardiac aging in humans.Atopic dermatitis (AD) is a common inflammatory skin disease, and its pathogenesis is closely associated with microbial homeostasis in the gut, namely the gut-skin axis. Particularly, recent metagenomics studies revealed that the abundance of two major bacterial species in the gut, Faecalibact