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7% (p=0.001) and at 3months post-treatment by 2.1% (p0.001); their SMI returned to the baseline level at 9months post-treatment. SMI changes were weakly correlated with changes in body mass index (BMI) (Spearman ρ, 0.13; p=0.11). In multivariate analysis, SMI changes (per 5% decrease) were independently associated with significantly worse OS (hazard ratio 1.88, 95% confidence interval 1.58-2.23; p0.001) and RFS (hazard ratio 1.89, 95% confidence interval 1.61-2.20; p0.001). Progressive muscle loss was independently associate