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More attractively, the combination of PDA NPs and Fe-MSC-NVs further promotes M2 macrophage polarization, thereby suppressing wound inflammation. Through in vivo experiment, the Fe-MSC-NVs/PDA MN patch shows an excellent effect for diabetic wound healing. These features of antioxidation, antiinflammation, and pro-angiogenesis indicate the proposed composite core-shell MN patch is valuable for clinical wound healing applications.Immunoassay as a rapid and convenient method for detecting a variety of targets has attracted tremendous inter