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How to Choose the Best ADHD Medication for Adults With Anxiety and Depression When a person has both ADHD and anxiety or depression treating one of the conditions often improves the other. Mental health professionals typically prescribe antidepressants or a stimulant for depression in addition to an ADHD medication. Wellbutrin (bupropion) and Effexor (venlafaxine) are the most frequently prescribed antidepressants that are prescribed "off-label" for ADHD. These drugs inc