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This manuscript received endorsement from the International Society for Pharmacoepidemiology (ISPE). © 2020 The Authors. Pharmacoepidemiology and Drug Safety published by John Wiley Sons Ltd.Hepatocellular carcinoma (HCC) is a primary liver malignancy with a high global prevalence and a dismal prognosis. Studies are urgently needed to examine the molecular pathogenesis and biological characteristics of HCC. Chromatin remodelling, an integral component of the DNA damage response, protects against DNA damage-induced genome instability and tumorigenesis
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