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Moreover, circZNF652 and PTEN positively regulated the apoptosis of chondrocytes induced by LPS. PTEN overexpression reversed the inhibitory effects of circZNF652 siRNA silencing on cell apoptosis. Therefore, circZNF652 is overexpressed in OA and positively regulates LPS-induced apoptosis of chondrocytes by upregulating PTEN.My book, published in 2020, reconstructs the history of 'Aṣfūriyyeh, one of the first 'modern' mental hospitals in the Middle East. It uses the rise and fall of this institution as a lens through which to