https://osi-906inhibitor.com/l....arge-measure-compare
EXPERIMENTAL DESIGN HRD levels may be approximated utilizing different mutational signatures produced from next-generation sequencing information. We used this method on whole genome (n=311) and whole exome sequencing data (n=498) of both major and metastatic prostate adenocarcinomas (PRAD) to determine whether prostate cancer situations show clear signs of HRD in somatic tumor biopsies. RESULTS Known BRCA-deficient samples showed all previously described HR-deficiency linked mutationa
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