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We believe this study represents the first published finding of the moderation of the predictive influence of DI by WMC, and underscores the importance of evaluating how risk factors that are typically examined independently operate together.Despite promising immunotherapy strategies in human melanoma, there are few studies on the immune environment of canine melanocytic tumors. In humans, the activation of immunosuppressive cell subpopulations, such as regulatory T cells (Tregs) that express forkhead box protein P3 (FoxP3), the engagemen