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The Most Effective ADHD Medication For Adults Adults suffering from ADHD are usually prescribed stimulants. They aid in adjusting levels of two chemical messengers in the brain that control the attention. Strattera (atomoxetine) is the most effective adhd medication available for adults. It is available in a capsule that can either be taken with food or without food. Most people find it effective. It is also more effective than more sedatives, like amphetamine and methylphenidate. 1. Stratte