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The median DpR was-32%,-44%, and-50%, respectively (all P .01). In multivariate analysis, lung metastases were significantly associated with inferior DpR (P= .021), whereas hepatic metastases led to higher DpR (P= .024). Large metastases were associated with favorable ETS, whereas small metastases were correlated with higher DpR (P .001). ETS and DpR depend on the location and size of metastases in mCRC. These associations may establish the basis for further research to optimize the predictive accuracy of both parameters. This