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Abbreviations ALOX arachidonate lipoxygenase; ARNTL/BMAL1 aryl hydrocarbon receptor nuclear translocator-like; ATM ATM serine/threonine kinase; ATG autophagy-related; cGAMP cyclic GMP-AMP; CGAS cyclic GMP-AMP synthase; ER endoplasmic reticulum; FANCD2 FA complementation group D2; GPX4 glutathione peroxidase 4; IFNA1/IFNα interferon alpha 1; IFNB1/IFNβ interferon beta 1; MAP1LC3B/LC3 microtubule-associated protein 1 light chain 3 beta; MDA malondialdehyde; mtDNA mitochondrial DNA; NCOA4 nuclear receptor coactivator 4; PDAC pancreatic ductal adenocarcinoma; P