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The regular dysregulation of mTOR signaling in disease makes it an attractive therapeutic target, and several kinds of mTOR inhibitors have been developed. Nanoparticle-based mTOR modulators are predicted to target different cancers and deliver along with release medicines in a controlled fashion, leading to improved bioavailability and reduced side effects. This mini-review is concentrated from the molecular apparatus of nanoparticle-based mTOR modulator action along with th