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The present study investigated sub-regional variants in corpus callosum stability in ALS, and whether these reflect a relationship with all the development of unilateral or bilateral limb weakness. Practices Sporadic ALS patients had been categorized into unilateral (letter = 14) or bilateral (n = 25) limb weakness at the time of assessment and underwent diffusion tensor imaging. Probabilistic bundle-specific monitoring had been completed using MRtrix and TractSeg to parcellate the corpus