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estigations like bone marrow biopsy etc. Key Words Immature platelet fraction, Complete blood count, Central thrombocytopenia, Peripheral thrombocytopenia, Bone marrow failure, Peripheral destruction. To investigate the association of C4A null allele (C4AQ with systemic lupus erythematosus (SLE) and determine the clinical presentation of SLE in relation to C4A null allele. Descriptive study. Armed Forces Institute of Pathology (AFIP), Rawalpindi, Immunology Department, from December 2018 to December 2019. Patients referred to AFIP, wh