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To evaluate the effect of altering vaginal pH on induction of labor in full-term pregnancies using Misoprostol. This randomized controlled trial was conducted at Kasralainy Hospital, Cairo University, Egypt and Algezeera Hospital, Egypt. A total of 218 healthy term primigravida pregnant women who were scheduled for pregnancy termination were recruited in the study. The included patients were divided into three groups; Group A Those who received normal saline vaginal wash (0.9% NaCl), Group B those who received alkaline vaginal wash (5%