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Objective The objective of this research was to evaluate the effects of bromelain (derived from Ananas comosus) upon periodontitis in rats. Materials and methods Twenty-four rats were separated into groups control, periodontitis, and bromelain treatment. Bromelain was administered daily by intraperitoneal injection for 20 days. Periodontitis was induced by ligature around the first molars. Oral parameters and blood biomarkers were measured. The histopathological evaluation of the hepatic tissue was performed. Bromelain treatment signifi
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