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Background A large number of existing reviews have discussed the role of the gut microbiota in affective disorders, though syntheses have been overwhelmingly narrative in their focus. Method In this correspondence, we compliment Sanada et al. (202 on their recent systematic review of the gut microbiota in Major Depressive Disorder (MDD), the first to incorporate a meta-analysis. We also comment on how this synthesis should be extended in future research. Results Sanada et al. (202 conducted a meta-analysis of alpha diversity in par