https://www.selleckchem.com/pr....oducts/ly3039478.htm
Hydrostatic pressure (HP), increasing by 1 atm per 10 m in the ocean, perturbs many cellular processes, for example, by rigidifying membranes and disturbing protein folding and ligand binding. Membranes can be fluidized to work under high HP by increasing unsaturated fatty acids, for example, docosahexaenoic acid. Over generations, some deep-sea proteins have evolved intrinsic resistance to HP, but often incompletely. These may be protected from HP with piezolytes, small organic molecules with pressure-counteracting properties. The ke