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BACKGROUND AND AIM Male sex is a risk factor for hepatocellular carcinoma (HCC). Diabetes mellitus (DM) is associated with a doubled risk of HCC in patients with chronic hepatitis B (CH. We examined the relationship between serum total testosterone and HCC risk in male CHB patients with DM. METHODS We performed a retrospective cohort study of male CHB patients with DM between 2000 and 2017 using a territory-wide electronic healthcare database in Hong Kong. DM was defined by use of anti-diabetic medications, hemoglobin A1c ≥6.5%, and/
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