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Into the MPS brain, the major lysosomal enzyme dysfunction leads to accumulation of primary glycosaminoglycans (GAGs) with gangliosides (GM2 and GM3) being the major secondary storage services and products. With a focus in the neuropathology, a period course test had been performed in MPS I, MPS IIIA, MPS VII (serious and attenuated designs) in order to comprehend the relative timing and amount of GAG and ganglioside buildup and