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We demonstrate a 4,294,967,296-quadrature amplitude modulation (QAM) based Y-00 quantum stream cipher system carrying a 160-Gb/s 16-QAM signal transmitted over 320-km SSMF. The ultra-dense QAM cipher template is realized by an integrated two-segment silicon photonics I/Q modulator.In this paper, a flexible non-orthogonal multiple access (NOMA) based optical orthogonal frequency division multiplexing (OFDM) modulation scheme, called non-orthogonal hybrid optical OFDM (NOHO-OFDM), is proposed to increase the achievable data rate of the vi