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Herein, we aimed to comprehensively calculate the association between HMs and PAHs (three bloodstream HMs and six urinary PAHs metabolites) co-exposure and joint disease. Using information through the nationwide health insurance and Nutrition Examination study (NHANES), 2003-2016, we included 9735 grownups, of whom 2464 had total arthritis, 1371 had OA, and 468 had RA. The logistic regression design had been conducted to calculate the single effectation of HMs and PAHs on joint disease. Moreover, weigh