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001), and cardiac output (5.1 ± 1.2 versus 5.9 ± 1.5 L/min, p less then 0.001), which indicated an increased afterload on the left ventricle. After the hand-grip exercise, FFR significantly decreased from 0.86 ± 0.06 to 0.84 ± 0.06 (p less then 0.001). A percent increase in systolic blood pressure and cardiac output after hand-grip exercise strongly correlated with ΔFFR (r = - 0.65, p less then 0.001 and r = - 0.55, p less then 0.001, respectively). An increase in cardiac output with hand-grip exercise during pharmacological hyper
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