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indicus yy-1 for relieving the oxidative stress. The transcriptional level of genes related to Cr(VI) and Hg(II) reductases and antioxidant enzymes were up-regulated, indicating that the reductases have participated in the reduction of Cr(VI) and Hg(II), and SOD and CAT served as the vital antioxidant enzymes for defending the oxidative stress. This work provides a deep insight into the mechanism of antioxidant stress in Cr(VI) and Hg(II) reducing bacteria, which helps seek the highly resistant heavy metal reducing bacteria.Degradable and