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The factors associated with callus hotspots were number of calluses (Adjusted odds ratio (aOR) 1.540, = .003), static forefoot peak plantar pressure (SFPPP) (aOR 1.008, = .001), and body mass index (aOR 0.912, = .029). Patients with a higher SFPPP were more likely to have callus hotspots suggesting that SFPPP might contribute to callus inflammation. SFPPP has the potential to be a useful predictor of callus hotspots in people with diabetes and at the same time provide information for off-loading interventions to prevent callus hotspots