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ADHD Stimulant Medication Stimulants improve symptoms like inattention and hyperactivity The effects are usually seen within 30 to 60 minutes. They are the first line medication for people with ADHD. Stimulants alter the activity of neurotransmitters, such as dopamine and naradrenaline in the tiny gaps called synapses between neurons. They also enhance the communication between neurons. Methamphetamine Methamphetamine (also known as meth crystal, ice, crystal or speed) is