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Collectively, these findings demonstrated that Rac1 inhibition delayed the EPCs degeneration and its potential mechanism may be associated with Wnt/β-catenin pathway regulation, which may help us better understand the association between Rac1 and CEP degeneration and provide a promising strategy for delaying the progression of IVDD. © 2020 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley Sons Ltd and Foundation for Cellular and Molecular Medicine.As the first discovered organoboron compound with pho