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However, a geologic formation with good geotechnical characteristics, such as a low compressibility potential, was encountered at a depth between 7 and 16 m, which coincides with the third layer of the seismic refraction method. The results of the three methods confirmed that the depth to most competent layer must be located before the foundations of engineering constructions are sited. To analyze the action of strontium ranelate (SR) and melatonin in isolation or in association in knees, liver and kidneys of rats Wistar with induced o