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Are the Most Effective ADHD Medication For Adults The most common prescription medication used by healthcare professionals to treat ADHD among adults is stimulants. They work by increasing levels of certain chemicals (neurotransmitters) in your brain, which improve attention and reduce impulsivity. Antidepressants such as Strattera (atomoxetine) and Zyban/Wellbutrin (bupropion) can also help manage ADHD. They boost the levels of norepinephrine inside your brain. Stimulants Stimulants,