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ADHD Medication - Stimulants Stimulants alter how the brain releases chemicals which influence concentration. Doctors usually start patients with ADHD on stimulants and move to the highest dose that helps them. Antidepressants are also used by people suffering from ADHD (not just for depression). These drugs are based on the same chemicals that stimulants do, however they are less harmful to the body. Stimulants The first drug that doctors prescribe for ADHD is stimulants. They work by increasing levels