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Finding the Best ADHD Medication For Adults Many adult ADHD treatment plans are based on medication. However, finding the right medication and dosage can be difficult. Stimulants: These medications are used to treat both inattention and hyperactivity. They work by increasing levels of chemicals that transmit messages between nerve cells. They are typically taken several times a day and can be effective in less than an hour. Stimulants Most doctors begin with stimulants to treat ADHD. work by