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05), and the expression of genes related to methylation were downregulated (P less then 0.05) or showed a downward trend (P less then 0.1 in the liver and spleen. These data indicated that goats feeding Zn-Met during pregnancy increased the offspring liver organ index without change in the genomic DNA methylation. It is speculated that the regulation of zinc finger protein Sp3 adjusted by blood zinc indirectly regulated the expression of methylation-related genes in the liver and spleen of the kid goats, thus enhancing the developmen