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6% and 1.7 percentage points ( 0.05). Death from any sepsis diagnosis was reduced 4.5% ( 0.01). Death from severe sepsis and septic shock both was reduced by 5% ( 0.01) and 6.5% ( 0.01), respectively. After the implementation of multimodal sepsis performance initiatives, we observed a higher prevalence of sepsis secondary to screening but a lower prevalence of severe sepsis and septic shock, an improvement in compliance with the sepsis bundle interventions bundle, as well as reduction in hospital readmission and all- cause mortal