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The results of this study will be published in a peer-reviewed journal, and provide reliable evidence for different CHMIs on CPHD. The findings will provide reference for evaluating the efficacy and safety of different CHMIs for CPHD, and provide a helpful evidence for clinicians to formulate the best adjuvant treatment strategy for CPHD patients. INPLASY2020120004. INPLASY2020120004. The impact of surgical margin status on the survival of patients with extremity soft tissue sarcoma (STS) remains to be clearly defined. The evidence regar