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This is a clear advantage for polyvinyl alcohol hydrogels, that are somewhat missing the possibility to alter the frequency for the maximum physical loss, due to the physical cross-link system involved-namely, that of the borate esterification.Noonan syndrome (NS) is a dominant clinically variable and genetically heterogeneous developmental disorder caused by germ-line mutations encoding components of the Ras-MAPK signaling pathway. A few studies have investigated psychopathological features occurring in individuals with NS, although the