https://acitretinagonist.com/i....nf%ef%bb%bfluence-in
Interestingly, the phrase of serum response factor (SRF), an important transcription factor for myogenesis procedure, extremely increased and decreased in mRNA and necessary protein amounts with the respective overexpression and knockdown of MEG3. Dual luciferase reporter assay showed that MEG3 could attenuate the decrease of luciferase activity of SRF induced by miR-423-5p in a dose-dependent fashion. MEG3 overexpression could alleviate the inhibitory impact on SRF and myoblast differ