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abdominal crypts exhibited fewer spherical organoids with minimal Wnt/β-catenin target gene appearance, recommending a minimal tumor-initiation capability. Wnt3 expression was decreased into the lack of LAT1 into the abdominal epithelium, suggesting that loss of Paneth cells as a result of LAT1 deficiency paid down the risk of tumor initiation by reducing Wnt3 production.LAT1 affects abdominal tumefaction development in a cell-extrinsic manner through decreased Wnt3