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Bacterial load into the lungs wasn't suffering from the procedure, as well as in vitro equivalent dosage of Marimastat and Ilomastat did not affect PAO1 development and viability, verifying why these particles do not have additional anti-bacterial task. Our outcomes show that inhibition of protease task elicits anti inflammatory results in cystic fibrosis (CF) mice with severe P. aeruginosa lung illness. Thus, Marimastat a