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Electrospray ionization mass spectrometry supported by mobility classification (ESI-DMA-MS) is a strong technique for a comprehensive analysis of organic and inorganic clusters and small nanoparticles. In-depth understanding and optimization of the electrospray process are key for unlocking new fields of application and for extension of the accessible range of data. We show that the combination of mobility-classified mass spectrometry (DMA-MS) with an electrospray operated in a well-defined cone-jet mode is capable of providing a full p