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Hypoxia is a type of pathological process in various clinical conditions. Nevertheless, there was nonetheless the lack of effective anti-hypoxia energetic substances. Agaricus bitorguis (Quél.) Sacc Chaidam (ABSC) is an unusual crazy edible macrofungus that grows underground at high altitudes. Herein, intracellular phenolic acids-rich portions (IPA) were obtained from ABSC ZJU-CDMA-12, plus the architectural characterization and anti-hypoxia task of IPA on PC12 cells were eluc