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Most Effective ADHD Medication For Adults The majority of adults report that medication helps to reduce their ADHD symptoms, allowing them to concentrate and feel more relaxed, as well as have better relationships. The use of medication can also aid in other treatment options like psychotherapy. Adults with ADHD are more likely to benefit from stimulants. They include amphetamine and methylphenidate compounds. Adults may take long-acting medicines that are slow-acting but last for 3 to 6 hours, or short-acting medications multiple times pe