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Overall, our results highlight the functional role of STP in regulating the inducing and propagation of transient synchronous activity, and they may inspire testable hypotheses for future experimental studies.Epilepsy involves a diverse group of abnormalities, including molecular and cellular disorders. These abnormalities prove to be associated with the changes in local excitability and synaptic dynamics. Correspondingly, the epileptic processes including onset, propagation and generalized seizure may be related with the alterations of