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The Global Pertussis Initiative is an expert scientific forum that publishes consensus recommendations concerning pertussis for many regions of the world. Here, we give recommendations for the primary vaccination of infants in those countries where whole-cell pertussis (wP)- and acellular pertussis (aP)-containing combination vaccines are used in parallel. We performed a selective literature review concerning the influence of mixing wP- and aP-containing vaccines for primary immunization of infants on safety, immunogenicity, and effectiv