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The overall estimated pooled prevalence of the pathogens among the human population was 4.27% (95%CI 4.03-4.51%; p less then 0.001) with significant heterogeneity (I2 = 99.50%). The top three highest prevalent pathogens were M. tuberculosis (30.90%; 22.75-39.04%; p less then 0.001; I2 = 99.70%) followed by Toxoplasma gondii (21.93%; 6.23-37.61%; p less then 0.001; I2 = 99.30%) and hepatitis E virus (18.29%; 11.72-24.86%; p less then 0.001; I2 = 96.70%). However, there is a knowledge gap about the listed pathogens regarding the o