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(1) Background. Patients are increasingly using physician online reviews (PORs) to learn about the quality of care. Patients benefit from the use of PORs and physicians need to be aware of how this evaluation affects their treatment decisions. The current work aims to investigate the influence of critical quantitative and qualitative factors on physician review helpfulness (RH). (2) Methods. The data including 45,300 PORs across multiple disease types were scraped from Healthgrades.com. Grounded on the signaling theory, machine learning