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Finding the Best Medication For ADHD The most commonly prescribed medication for ADHD is stimulants. include amphetamines and methylphenidates. Short-acting stimulants are effective within less than a minute and should be taken several times a day. Long-acting stimulations last up to 16 hours and are taken once a day. Your doctor might prescribe antidepressants or other kinds of drugs "off-label" to treat ADHD symptoms. These medications are approved to treat conditions such as a